PPR at CA3-CA1 synapses assessed at various interstimulus intervals in acute hippocampal slices from 4- to 8-month-old hAPP J20 and littermate wild-type control mice. CTZ was again added to prevent Abo-induced AMPAR desensitization (wild type and hAPP both n= 6 slices from three mice). Representative traces show responses at 50 ms intervals. Scale bars, 0.2 mV and 10 ms. Two-way ANOVA with post hoct test and Sidak correction. Error bars represent SEM.*p< 0.05,**p< 0.01,***p< 0.0001, and ns, non-significant.
