MCF10DCIS control (Ctrl) or RRAGC KO #C3 cells were injected subcutaneously in nude mice. At weeks 1, 3, or 5 post-inoculation, tumors were dissected, and sections stained with indicated markers. Representative images of week 5 tissue sections of different tumor xenografts labeled for basement membrane collagen IV. Bottom row in show week 3 sections labeled for collagen IV. Arrowheads point to collagen IV deposition between RRAGC KO cells. N, nucleus; n, necrosis; s, stroma.
