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Model of how nuclear localization of condensin I affects mitotic chromosome reorganization. Here, we illustrate the process of mitotic chromosome reorganization by viewing the cross-section of a pair of sister chromatids down their axes (top-left inset). Under normal circumstances (left), only condensin II has access to chromosomes during prophase and large loops are formed, pushing sister chromatids apart due to steric repulsion, completing sister chromatid resolution.44Following NEBD, small loops are formed by condensin I within the already-formed large loops, making folded (narrower) chromatids.11In the situation where condensin I is present in the nucleus during prophase (right), the premature formation of small loops, as well as large loops, will lead to reduced steric repulsion, resulting in incomplete sister chromatid resolution for some chromosomes. Then, at later stages of mitosis, although sister resolution is incomplete for some chromosomes, overall chromosome folding looks relatively normal. See alsoFigures S5andS6.

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