Protein Structure from Scientific Research

Peptide residues that were modified by 15 and 16, according to tandem mass spectrometry of a tryptic digest, were mapped to the structure of the Hla monomer (PDB:4IDJ) (C) or to the structure of the heptameric pore (D) (PDB:3ANZ) and are shown in magenta, whereas significant CSPs (CSP > 0.013) from the NMR titration are shown in red. The known binding site for phospholipid headgroups that trigger heptamerization is indicated with a green circle (under the “rim”).

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