Architecture of ShennongAlpha. ShennongAlpha applies the Systematic Nomenclature for NMMs (Fig. 2 ) and integrates ShennongName (Fig. 3 ) with a hexa-domain modular system to form its structure. The hexa-domain system is outlined in the light teal block. ShennongAlpha is structured into five layers, from shallow to deep. Layer 1: web and user interaction layer. In this layer, users can access the system via our ShennongAlpha Web (Fig. 4 ). Layer 2: algorithm and application layer. In this layer, we have specifically developed three applications customized for NMMs: ShennongName, ShennongChat (Fig. 5 ), and ShennongTranslate (Fig. 6 ). Users can access these applications on the corresponding pages of the ShennongAlpha Web. Layer 3: AI layer. In this layer, we have integrated the ShennongAlpha LLM system, allowing the ShennongAlpha to process and respond to data from different layers intelligently. Layer 4: search engine layer. In this layer, we have integrated the ShennongAlpha Search Engine customized for NMM-related data. Layer 5: knowledge base layer. In this layer, we have integrated the ShennongAlpha Knowledge Base to curate NMM knowledge. Arrows represent the allowed data interactions between different layers.