Bubble Plot from Scientific Research

For each dietary arm and time comparison, the top bar plots present the number of DAMs at each time point. An LMM was used for each comparison with a two-sided hypothesis test. Fixed effects included time point, baseline BMI, age and baseline physical activity level; participant ID was included as a random effect. Significance level was set to Benjamini-Hochberg-adjusted P <= 0.05 and absolute paired fold change greater than 1.2. The lower dot plots present the top eight significantly enriched WikiPathway metabolic pathways for DAMs using a Fisher’s exact test via the RaMP database. The color indicates the direction of the DAM, up or down in red or blue, respectively. The size of the dots depicts the number of metabolites related to the pathway. Pathways are ordered alphabetically.

DOI