Using pooled data from all five cohorts (n = 1767), performance shown for participants with MCI (n = 858). Results are shown using a single cutoff (blue) or two cutoffs (red). Note that AUC values are independent of cutoffs. To assess whether the observed difference in the statistics is significantly different from zero, we performed a bootstrap hypothesis test. The P value (two sided) was calculated as the proportion of bootstrap resamples (n = 2,000) where the absolute null-distributed statistic was greater than or equal to the observed difference. Differences between AUCs were assessed using DeLong statistics. Results were not corrected for multiple comparisons. Significant P values in the order as presented in the plot: <0.001, 0.046. Significantly higher than the MCI group, P < 0.05.
