Participants with results between the two cutoffs classified as intermediate. The number of participants in each group, stratified by AD pathology, is indicated in a. Data are presented as the observed percentage and the error bars as the 95% CI derived from the bootstrap distribution. The analysis combined data from the five different cohorts (n = 1,767). The same analyses restricted to the primary care cohort can be found in Extended Data Fig. 3. AD pathology was defined as CSF Abeta42:p-tau181 < 11.94 or positive visual read on amyloid PET if lumbar puncture was not performed (n = 87). To assess whether the observed difference in the statistics is significantly different from zero, we performed a bootstrap hypothesis test. The P value (two sided) was calculated as the proportion of bootstrap resamples (n = 2,000) where the absolute null-distributed statistic was greater than or equal to the observed difference. Differences between AUCs were assessed using DeLong statistics. Results were not corrected for multiple comparisons. Significant P values in the order as presented in the plot: 0.046, 0.003 (a); 0.035, 0.026 (c); 0.034, <0.001, <0.001 (d). a Significantly higher than group 1, P < 0.05. b Significantly higher than group 2, P < 0.05. c Significantly higher than group 3, P < 0.05.
