Multiancestry meta-analysis effect sizes for the association between percentage change in body weight and genotype at each locus. Dots represent the estimated percentage change in body weight, error bars represent the 95% CI for the estimate. For a and b , coefficients are estimated from a linear regression model, separately for each genetic exposure. Full dots represent statistical significance at P < 0.004 (Bonferroni adjusted for 14 independent tests). P values are two-sided and were calculated by dividing the coefficient values by their standard errors and observing the probability mass corresponding to equal or more extreme values from both tails of Student’s t distribution. Exact P values can be found in Supplementary Tables 5 and 6 . Total sample size is 6,750 for GLP1-RA and 4,210 for BS. Sample size per ancestry can be found in Table 1 .
