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The associated reduction in seizure frequency. A total of seven elsunersen (intrathecal) doses were administered between 13 March 2023 and 29 September 2023 (30.5 mg total). PB, phenobarbital; PHT, phenytoin; LEV, levetiracetam; LCM, lacosamide; OXC, oxcarbazepine; MDZ, midazolam; CBZ, carbamazepine; LDC, lidocaine; LTG, lamotrigine; ASO, antisense oligonucleotide, here elsunersen; CLB, clobazam; GBP, gabapentin; DZP, diazepam; ESL, eslicarbazepine. Corresponding aEEG traces are displayed in Supplementary Fig. 1a-g .

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