The effects of testosterone-associated rare variants (chr:pos:minor allele:major allele) on infertility in females (left: n cases/controls for F-ALL = 3,746/260,413; n cases/controls for F-EXCL = 3,012/261,147) and males (right: n cases/controls for M-ALL = 650/222,393) estimated using regression analyses. The effect sizes are aligned to the minor allele. Per gene, the variant with the lowest P value of all variants that reach exome-wide significance in UKBB WES analyses for testosterone is displayed, for all variants with nominally significant effects on infertility. Effect sizes (β and 95% CIs) for the variant effect on testosterone are to the left of each plot and effect sizes (ORs and 95% CIs) for the variant effect on infertility are to the right of each plot.
