Recent directional selection, as measured by trait-aligned SDSs (tSDSs) at the EBAG9 locus. The window of 10 kb around the lead variant associated with F-ALL is displayed, along with the location of nearest gene TSSs. The tSDSs are aligned to the infertility risk-increasing allele, wherein a positive tSDS indicates positive selection for infertility risk-increasing allele at the locus. The dashed lines indicate 2.5th percentile (%ile) and 97.5th %ile of SDSs. Left: a locus plot depicting genomic position on the x axis and tSDS on the y axis. The lead variant rs1964514 (open circle) is not present in the tSDS dataset and thus is assigned a score of 0. Right: a scatter plot depicting relationship between -log 10 of the GWAS P value for the variant association with F-ALL on the x axis and tSDS on the y axis.
