Manhattan Plot from Scientific Research

Genetic variants associated with M-ALL. Each point depicts a single SNP. The triangles represent SNPs that only reach genome-wide significance in all-ancestry GWAS meta-analyses. SNPs are annotated with the mapped gene. * The lead variant is reported in only one cohort. Summary statistics from whole-genome regression analyses were meta-analyzed using fixed-effect inverse-variance weighting in the METAL software to produce the displayed P values. The dashed line represents the multiple testing-corrected P value threshold of P < 5 x 10 -8, accounting for ~1 million independent variants in the genome.

DOI