Downstream analyses performed for each type of genetic analysis: lead variants were identified via distance-based pruning for all-ancestry and EUR-only GWAS meta-analyses; colocalization, genetic correlations (genome wide and local), genetic overlap and selection analyses were only performed for EUR meta-analyses due to the need for ancestry-matched LD information; rare-variant and gene-burden discovery tests were performed with WES data for the UKBB EUR-ancestry subset and replicated in individuals with WES data in G&H and whole-genome sequencing (WGS) data in deCODE.
