Differential gene expression of the HOXA locus and surrounding genes, with the top showing upregulated genes in BRCA1 deletion CRCs and the bottom showing downregulated ones; circle size reflects log 2 (fold change), while color indicates Benjamini-Hochberg-adjusted p -values from two-sided Wilcoxon rank-sum test (open circles denote p adjust > 0.05; n = 213). Panels a–e compare CRCs with MLH1 deletion to control CRCs, while ( f–i ) compare CRCs with BRCA1 deletion to control CRCs. Source data are provided as a Source Data file.
