Doughnut plots showing the fraction of metastases (n = 191) that harbor selected organotropic CIs (see legend for the assignment of secondary organs: li, liver; lu, lung; br, brain; chr., chromosomal arm; see also Supplementary Fig. 5 for a full representation of all organotropic CIs). The frequency of occurrence is color-encoded according to the legend shown on the right. Two-sided Fisher exact tests with Benjamini-Hochberg adjustment for multiple comparison were used (*, p adjust < 0.05; **, p adjust < 0.01, and ***, p adjust < 0.001). (1) p adjust = 3.80 x 10 -2 ; (2) p adjust = 1.14 x 10 -2 ; (3) p adjust = 2.48 x 10 -2 ; (4) p adjust = 3.80 x 10 -2 ; (5) p adjust = 4.10 x 10 -2 ; (6) p adjust = 7.80 x 10 -3 ; (7) p adjust = 3.80 x 10 -2 ; (8) p adjust = 4.85 x 10 -3 ; (9) p adjust = 4.22 x 10 -3 ; (10) p adjust = 3.08 x 10 -7.
