Distribution of CIs including losses and gains for CRC metastases ( n =191). (1) p adjust =2.46 x 10 -3 ; (2) p adjust =1.37 x 10 -6 ; (3) p adjust =5.57 x 10 -3 ; (4) p adjust =3.70 x 10 -4 ; (5) p adjust =5.96 x 10 -3 ; (6) p adjust =1.44 x 10 -4 ; (7) p adjust =4.97 x 10 -7 ; (8) p adjust =1.75 x 10 -2 . c , d Data are presented as combined violin and box plots (thick line in the box corresponds to median; lower and upper edges of the box indicating the first (Q1) and third (Q3) quartiles; whiskers extend to 1.5 times the IQR). Individual data points are presented using the jitter method. Kruskal-Wallis tests with Dunn posthoc tests (two-sided) and Benjamini-Hochberg corrections for multiple comparisons were used to test for statistical significance. *, p adjust < 0.05; **, p adjust < 0.01, and ***, p adjust < 0.001. Source data are provided as a Source Data file.