Representative recording of the effect of gelsenicine agonism on GluN1/GluN2B receptor currents. Galsenicine (10 M) was pre-applied together with glycine (10 M) for 20 s, followed by the application of of 10 M glutamate and 10 M glycine. The graphs on the right show the values of the potentiation (in %) induced by Gelsenicine and DAP-5 on the NMDAR current responses; n = 2. Mice in the 5 min and death groups received an i.p. injection of 0.24 mg/kg gelsenicine, control mice were injected with normal saline, and those in the Glycine + Gelsenicine groups were pre-treated with 1600 mg/kg glycine before receiving the same dose of gelsenicine. Data are presented as mean SD. * P < 0.05, ** P < 0.01 based on one-way ANOVA
