Manhattan Plot from Scientific Research

Manhattan plots showing associations from single variant testing ( A ) and gene-level testing ( B ). The red dashed lines represent thresholds for exome-wide significance ( A ; 4.3 x 10 -7 ) and Bonferroni significance ( B ; 2.7 x 10 -6 ). Genes and variants marked with an asterisk did not pass post hoc filtering (i.e., nominal association with a true phenotype or with both liver enzymes and metabolic dysfunction markers) and were not further analyzed.

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