Spearman’s correlation of ranks of gene differentially expression in R vs. NR pTRC and those in validated MANA- vs. flu/EBV-specific TIL, the genes were ranked by the fold change (log2) from top (upregulated in responding pTRC or MANA-specific TIL) to the bottom (downregulated in responding pTRC or MANA-specific TIL). Box plots represent minima maxima as whiskers, the median as the center line within each box, and the interquartile range (IQR) between 25 th and 75 th percentiles as the bounds of each box.