Representative image of a single EV obtained with dSTORM and corresponding quantification showing the % colocalization of L1CAM and alpha-Syn on Tetraspanin Trio+ (Tetra Trio+) EVs from SEC F3+F4; pooled serum from 5 individuals with PD was tested; scale bar, 100 nm. Data are represented as mean SD. Statistical significance was determined by one-way ANOVA (A) or students two-tailed t test (D).
