Importance of individual exposures, as assessed by a multivariable model including age, sex and all 25 exposures associated with mortality and proteomic aging that passed all sensitivity analyses ( n = 436,891). The importance of each variable was determined using a Wald test from ANOVA, and was calculated as the proportion of that variable’s Wald Χ 2 relative to the total model Χ 2 . Note that the y -axis values were transformed by taking the square root to improve visualization. Physical activity was measured using the International Physical Activity Questionnaire (IPAQ). LTPA, leisure time physical activity; OPA, occupational physical activity; PM, particulate matter.