The lysosomal lumen is acidic and hosts ~60 acid hydrolases, many of which degrade lipids. Lipids and membranous material destined for degradation comprise (1) dietary lipids from lipoprotein particles such as low-density lipoprotein (LDL), (2) endosomal membrane trafficking-derived membranes (3) autophagosomal membranes and autophagic cargo such as mitochondria, ER, or lipid droplets, (4) Golgi carriers that also traffick the acid hydrolases from the Golgi to lysosomes via mannose 6-phosphate receptor (M6PR), sortilin, or in the case of glucocerebrosidaseGBA1 via SCARB2, and (5) intraluminal vesicles generated by the ESCRT system. Created with Biorender.
