Results from CoxPH models for 13,872 participants within the 100KGP pan-cancer cohort with complete clinical annotation. The models account for the effects of age, sex, genetically inferred ancestry, pretreatment chemotherapy and cancer stage. Left, pan-cancer HRs with 95% CIs. Right, a heatmap of HRs for different cancer histologies, including the I 2 score from a meta-analysis using a random effects model across all histologies. Significance was calculated using Cochran’s Q test. Multiple hypothesis adjustments were performed using the Benjamini-Hochberg method, applied by row. Individual P values were calculated using a two-sided Wald test within the Cox model. * P < 0.05, ** P < 0.01 and *** P < 0.001.
