Volcano plot showing results from a Poisson model predicting observed nonsynonymous mutations as a function of TCRA T cell fraction and other covariates (age, tumor mutation burden, sex and disease type). The plot shows the estimates and -log 10 ( P ) for the TCRA variable, highlighting genes where observed mutations significantly depend on T cell immune infiltration (hot tumors denote high levels of immune cell infiltration; cold tumors lack immune cell infiltration). Point size represents the number of patients in the cancer cohort with nonsynonymous mutations, excluding patients with hematological cancers. Genes tested were limited to known cancer drivers from the Cancer Gene Census 47 .
