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Acute application of the group 1 mGluR1/5agonist DHPG (50 M, 5 min) induces a long-lasting depression of fEPSPs in hippocampal CA1. Replacing the GluN2B CTD with GluN2A significantly enhanced mGluR-LTD in B2A mice relative to WT littermates (WT: 83% 5%,n= 7; B2A HOM: 65% 4%,n= 6;*p= 0.017, unpaired t test).

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