Illustration from Scientific Research

Schematic of the predominant NMDAR assemblies in hippocampal CA1 and binding sites for GluN2A and GluN2B subtype-selective compounds. The GluN2B competitive antagonist conantokin-G (Con-G) blocks the glutamate binding site on 2A/2B tri-heteromers and 2B di-heteromers. The negative allosteric modulator (NAM) of GluN2A, MPX-004, binds to the N-terminal domain (NTD) of 2A di-heteromers and 2A/2B tri-heteromers.

DOI