HCM locus-to-gene mapping and prioritization based on cardiac expression. Locus-to-gene mapping was done using the OpenTargets 13 V2G pipeline (release of 12 October 2022) for all 68 lead variants at the HCM MTAG loci and using FUMA 14 for the HCM MTAG summary statistics (see Methods for detailed parameters). Of 164 genes mapped using both FUMA and OpenTargets (top 3 genes per locus), 26 were prioritized because of either high specificity of LV expression using the bulk RNA-seq data of the GTEx project 38 release v.8 and/or high expression in cardiomyocytes using snRNA-seq data 15 . See Methods and Supplementary Tables 12 and 13 for details. Panel a was created using BioRender.com .
