Scatter Plot from Scientific Research

Rare (MAF < 10 -4 ) LoF variant association analyses with HCM versus controls performed for all 26 genes using sequencing data in up to 2,502 unrelated HCM cases and 486,217 controls from four datasets followed by IVW meta-analysis. Association of rare synonymous (SYN) variants was also performed as a negative control. Results shown restricted to two genes ( ALPK3 and SVIL ) reaching the Bonferroni-corrected threshold of P < 0.0019 (0.05/26) in the IVW meta-analysis. Filled circles and error bars represent the OR and their 95% CI, respectively, from the meta-analysis for LoF (blue) and SYN (red). P values shown are not corrected for multiple testing. Full results appear in Supplementary Table 16 .

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