Cumulative all-cause mortality and adverse HCM outcomes after HCM diagnosis in 382 HCM cases from the UKB (a, b) and cumulative all-cause mortality in 683 HCM cases from GeL (c), stratified by PGS in the highest and lowest quintiles. Adverse HCM outcomes include death, stroke, cardiac arrest, implantable cardioverter-defibrillator implantation, septal reduction therapy (alcoholseptal ablation or surgical myectomy), LVAD implantation or cardiac transplantation. HR calculated using Cox proportional hazards model, adjusted for age, age 2, sex and first ten genetic PCs, with two-sided P value.
