Line Plot from Scientific Research

Cumulative major adverse cardiovascular events (MACE) among 214 sarcomere-positive relatives of HCM index patients stratified by PGS EMC above or below the median. MACE was defined as a composite of septal reduction therapy, cardiac transplantation, aborted cardiac arrest, appropriate defibrillator shock or sudden cardiac death. To avoid inflation of PGS performance resulting from sample overlap, PGS were rederived from GWAS leaving out the cohort that the PGS was being evaluated in (GeL PGS GeL , EMC PGS EMC ). HR calculated using Cox proportional hazards model, adjusted for sex, first four genetic PCs, and genetic relatedness matrix, with two-sided P value.

DOI