HCM prevalence and risk in UKB across the spectrum of PGS, demonstrating significantly higher HCM prevalence in individuals with the highest PGS (top centile, n = 3,394), compared with the median (n = 68,587) and lowest groups (bottom centile, n = 3,431). Effect estimates generated using logistic regression adjusting for age, age 2, sex and top ten genetic principal components (PCs), with unadjusted two-sided P value. Data are presented as effect estimates with 95% CI.
