Manhattan plots representing the common germline variants with MAF >= 1% included for GWAS in MCPS and UKB Europeans for ASXL1-CH. Unadjusted two-sided P values on the y axis were derived from the P value-based method implemented using METAL software. Five novel loci from the meta-analysis of MCPS and UKB (purple) were identified as genome-wide significant (P < 5 x 10 -8), with the nearest gene of the leading genetic polymorphism annotated for the respective locus. Previously reported associations from European populations are indicated in light blue and novel associations identified in the European population in our study are indicated in dark blue.
