rs187319135 identified as genome-wide significant from overall CH, and TET2 -CH and SF3B1 + SRSF2 -CH. Overall and gene-specific CH risk estimates conferred by the minor allele (T) are shown here for 136,401 MCPS participants. ORs and unadjusted two-sided P values were derived from Firth logistic regression implemented using REGENIE software. Risk estimates are shown when both CH or gene-specific CH cases and controls have minor allele count (MAC) >= 1. Risk estimates for UKB were not included owing to the absence of risk allele (MAC = 0) in CH individuals. Measures of center represent the ORs; error bars, lower and upper bounds of the 95% confidence intervals of the ORs. Full circles represent significant associations ( P < 0.05); hollow circles represent non-significant associations ( P >= 0.05).
