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Association between CH or gene-specific CH (outcome) with LTL PRS (predictor) adjusted for age, sex and smoking status. In total, 124,659 individuals who were not included in the LTL GWAS in a and with proportion of European genome and smoking status data available were included for analysis here. Only CH genes identified in at least ten individuals are shown. Beta coefficients and P values were derived from a logistic regression model. Measures of center represent the beta coefficients; error bars, lower and upper bound of the 95% CI of the beta coefficients. Full circles represent significant associations (P < 0.05); hollow circles represent non-significant associations (P >= 0.05).

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