Intra-population comparison of the frequency of all CH and gene-specific CH among individuals with varying degrees of European and non-European (Indigenous American and African) genome. Only CH driver genes identified in at least ten individuals are shown here. Beta coefficients and unadjusted two-sided P values were derived from a logistic regression model with all CH or gene-specific CH as the outcome and with the proportion of European genome as the predictor, adjusted for age, sex and smoking status. In total, 134,255 individuals with RFMix-inferred ancestry and smoking status available were included for analysis. Measures of center represent the beta coefficients; error bars, lower and upper bound of the 95% CI of the beta coefficients. Full circles represent significant associations ( P < 0.05); hollow circles represent non-significant associations ( P >= 0.05).
