Scatter Plot from Scientific Research

Sex-stratified observed DNM rates (left) and average liability (right) (see subjects and methods). In addition to the comparisons versus siblings, autistic probands with motor or cognitive difficulties were compared directly to sex-matched autistic individuals without these co-occurring conditions (with versus without). Limiting the analysis in (B) to ultra-rare DNMs in ancestry-matched autistic females and siblings showed well-balanced synonymous DNM burden (p= 0.42; Figure S28).

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