Illustration from Scientific Research

Alignment of M1R extracellular domain in 11 viral strains within Orthopoxvirus. Different colors indicate the degree of conservation at different sites: clear is completely consistent, followed by light blue, and the site with the greatest difference is represented by the deeper blue. Above the sequence, the secondary structures, such as α helices and β sheets that correspond to the amino acid positions, are represented. The red dots indicate the key residues on the M1R protein that are associated with the binding to M1R-01 (corresponding to the results in b ).

DOI