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Experimental design: Balb/c mice were administered intranasally (IN) with 10 mg/kg of Tri-M1R-01 or an anti-SARS-CoV-2 Nb (NB10) as a control. Thirty minutes after the administration, mice were IN challenged with a lethal dose of VACV and survival was monitored. Five days post-infection, lungs, spleens, and blood were collected for subsequent analysis.

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