Line Plot from Scientific Research

Normalized disruption scores are plotted for a simulated contact frequency map containing a TAD across six types of perturbation. Each perturbation was added at 100 different degrees. The images shown correspond to the final degree—the maximum perturbation added. The line plots show the disruption scores obtained by comparing the original map (top left corner) with each perturbed map. The maps, corresponding to the incremental increases in perturbation, are shown alongside the change scores in Extended Data Figure 9. Noise is added by introducing random values drawn from a Gaussian distribution to the maps. Dashed lines represent the correlation version of the method and solid lines the MSE version. Loops were excluded from the analysis since there are no loops intended to be created in these plots.

DOI