Model comparing natural IL-23 signaling through IL-23R and IL-12Rb1 (left, PDB ID: 6XDQ) vs. signaling through IL-23IL-10 cytokine adaptors (right) which dimerize IL-10Ra and IL-10Rb. Model of IL-23IL-10 adaptors is comprised of IL-23p19 binder VHH 37D5 and IL-23p40 binder VHH 22E11 and IL-23p19 (PBD ID: 4GRW) overlaid with structures of IL-10 receptor complex (PDB ID: 6X93).
