For each molecular dynamics water-binding site found in both or one cryo-EM map, the cryo-EM peak density is plotted against the molecular dynamics peak water density; the contours display the 5%, 25%, 50%, 75% and 95% probability densities from kernel density estimation ( d ). Pearson’s correlation coefficient and P value, two-sided hypothesis test for 0 correlation, are reported ( P = 3.2 x 10 −19 ).
