Structure-based sequence alignment of the presumed catalytic motifs in ScVip1 PD , E. coli AppA, and the multiple inositol polyphosphate phosphatase MINPP from Bacteroides thetaiotaomicron . The RHxxR motif is conserved among all enzymes, while the proton donor aspartate in EcAppA is replaced by Glu991 in ScVip1 PD and by an alanine residue in MINPP.
