Heatmap from Scientific Research

Amino acid residue map of RUNX1 Runt domain (columns). In each row, RUNX1 interface residues involved in interaction with each protein partner (rows) are highlighted by black. Rows are hierarchically clustered. Top: residue 3D location annotations (core, intermediate, surface), VEST and FoldX scores of the most damaging mutations targeting each residue. Color darkness indicates mutation impact: damaging (VEST) or destabilizing (FoldX).

DOI