Schematic of ALDH1A3 and metabolic states. ALDH1A3 acts through two different sources of acetyl (Ac)-CoA production: high glucose flux generates high levels of pyruvate, leading to Ac-CoA in ALDHHighcells, while ALDHLowcells preferentially uptake acetate as an Ac-CoA source. ∗p< 0.05;∗∗p< 0.01;∗∗∗p< 0.001;∗∗∗∗p< 0.0001. See alsoFigures S3andS4andTable S3.
