Protein Structure from Scientific Research

Structure of Cas12a with a 5-bp R-loop shown in surface representation. Top zoomed-in view highlights the WED and REC1 contacts of the 5-bp R-loop. Portions of REC1 that do not contact the R-loop have been removed for clarity. Bottom zoomed-in view highlights the R-loop-DNA junction that sits atop the bulky RuvC loop.

DOI