(Left) Individual traces of dynamic insulin secretion stimulated by glucose (15 or 6 mM) or KCl (30 mM). Basal glucose was 3 mM. Average responses from ND donors are illustrated with solid teal line, and average responses from donors with T2D are shown in the dashed salmon line. Floating dot plot inserts illustrate the heterogeneity in insulin AUC for the corresponding section of the perfusion curve (salmon dots illustrate the responses from donors with T2D). Middle panel shows islets stimulated with leucine (5 mM) alone or in combination with 6 mM glucose, as indicated. Right shows islets stimulated with oleate/palmitate (1.5 mM, 1:1 mix) alone or in combination with 6 mM glucose, as indicated.
