The risk of 20 ORMs in highly genetically predisposed individuals (top 20% PGSBMIversus remaining 80% PGSBMI); adjusted hazard ratios were obtained. Our analysis was deemed to have replicated known causal relationships if the associations exhibited a p-value below the nominal threshold, and 15 of 20 ORMs reached this threshold. Those replicated in our cohort were used for the subsequent subgroup analysis. Although replicated, associations with coronary artery disease and venous thromboembolism did not reach a Bonferroni threshold (0.05/20), thus warranting cautious interpretations.
