Calcification (Alizarin red S stain, arrows point at calcium deposits; scale bars, 100 μm; scale bars inset, 20 μm), within the brain parenchyma of a individual with AGS due to TREX1 mutation (c.598G>A p.Asp200Asn het) and in the brain of GIFN mice (representative fromn= 5 mice at 16–24 weeks of age).
