Left: Representative loop calls (black boxes) in a Hi-C map from African elephant primary fibroblasts, chr1:18.5–21.5 Mb, available interactively at https://t.3dg.io/3d-mammoth-Fig-4A. Center: Aggregate peak analysis (APA) of in situ Hi-C data from Asian elephant skin using African elephant loop list at 10-kb resolution. The central bin sums contacts from 10-kb-by-10-kb pixels surrounding each loop; other bins correspond to translations of the loop pixel set. Enrichments of the central bin vs. the average for each corner (black box) are shown, indicating presence of loops in aggregate. Right: APA using the same loop list repeated on mammoth PaleoHi-C data.
